World giant drug manufacturers have been toying around with researching, a street marketable cure, for dengue fever, over 70/years. It has cost the world citizens thousands of children’s and infant’s lives. When will families have their fill of this carnage?
Attempting to find out why, known and newly scientifically endorsed treatments, have not become globally administered around the world, we have only to read a damning report published by the World Health Organization. Reading the targeted report, gives us but a glimmer of hope, to understanding why a lid is kept on natural alternative treatments you can do at home to treat dengue fever. In just 24/hours, children and infants afflicted with dengue fever can be on the road to recovery.
Treating Aids victims became profitable– why? Because those who were poor in the western nations, with proper connections in their treatment plans received, as it were, government backed certified subsidy cards to cover their grossly high priced Aids/HIV treatment drugs such as they were/are. Friends of mine shopped at drug store pharmacies, that became their treatment pipeline centers, to extend their beautiful but often tragic lives. This luxury treatment is not extended to poorer nations, on the scale needed, especially in Africa. It is my reasoning, the poor are both exploitable and expendable unless they become a viable asset in the world of profiteering, political, financial, or in the healthcare industry, that has become riddled with stock market driven for-profit incentives.
Aloe Vera, Tea tree oil, Coconut, papaya, camote/sweet potatoes, tawa tawa, and neem, to name but a few plants and trees, for an eternity, are well known, documented, and scientifically endorsed antiviral natural resources to cure not only dengue fever but cancer and other mainline diseases around this planet for which the popular lie is told; “There are no known cures”.
Reading the subject material for the posting of this page, brought me a giant step closer to truly understanding why children and infants, even multiple siblings in some families, will continue to die. Until profitable drugs, vaccines, and vector control schemes, come to market, government subsidized if need be, all the misery caused by the very fragile and delicately constructed mosquito will be given, star billing, as the number one exponentially growing world pandemic.
Finding a control or cure for dengue fever, over the past 70/years, has been about street market value. Who will be held accountable for the great loss of lives, past, present, and tomorrow because financial priorities trumps sanctity of human lives.
When excessive profits can be made, even if government subsidies becomes the means of acquiring massive wealth– a no doubt deemed as safe toxic cure, will be known around the world. Assured to be only implemented where it has political and government backers for its greed ridden driving forces.
Following are only marginal quote extractions from pages 3-6, &11 of a 101 page World Health Organization report. Underlining and italics is supplied by the blog author.
This posting has been prepared solely in public interest for educational purposes. The
quoted materials is in the public’s right to know and have free access to materials affecting the lives of all world citizens. No commercial value is intended in the use of this material.
Antiviral Research And Development Against Dengue Virus
pg. 3 A short historical view on antiviral research and therapies
The antiviral drug field came of age in the next decades with the first antiviral molecule finding its way to the clinic: Gertrude B. Elion discovered acyclovir(2) a scientific breakthrough for which she was later awarded the Nobel prize in 1988. The subsequent emergence of AIDS in 1981, and the following pandemics drastically changed the field of antiviral research, allowing the widening of concepts, technical developments, rules, and business.
pg. 3,4 Lessons learned from recent viral diseases and pandemics
HIV and HCV: chronic invaders
The most important lesson comes from the following great achievement: it is possible to control a chronic infection of a very sophisticated virus, such as HIV, that hides inside the chromosomes of the infected cell. Although the victory is not total yet, it has profoundly changed the fate of the pandemic victims, at least in western countries. After being inspired by other research fields, anti-HIV research has “infected” other field of antiviral research and will continue to do so. Remarkably, after the identification of HIV, the control of HIV through antiretrovirals originated from a collective effort on a wide variety of scientific and medical fields, including efficient transfer from academia to the corporate world.
HCV (genus Hepacivirus ) and DENV (genus Flavivirus) belong to the same viral family Flaviviridae sharing similar genome organization and replication strategies. Initially, research conducted on dengue virus (DENV) was the actual starting and inspiration point for HCV research, when it became known that HCV had a flavivirus-like genome. Presently and conversely, knowledge and strategies gained from the successful drug discovery and design process against HCV can now be translated back to the DENV research field.
pg. 4 SARS and Influenza (H5N1 and H1N1): “hit and run” viruses
The optimistic say that social networks and cell phones make information travel much faster. Perhaps the true challenge is elsewhere: making people believe and adhere to an “official” information, as exemplified with the recent H1N1 crisis and the unsuccessful vaccination campaign. In any case, this crisis has been the best advocate for antivirals as a complementary strategy to prevention and vaccination.
In the case of influenza, the size of the market has been the main booster of anti-influenza drug development. This includes the availability of patients for clinical trials, and the fact that a potential devastating pandemic would undoubtedly provoke stockpiling of antivirals in the time-window into which an appropriate vaccine would available.
pg. 5 Infected cell assays
In both cases (Herpes and AIDS), infected cell cultures provided the antiviral read out, before purified targets were available and could be used. In these assays, compounds are tested individually to see if they either cure an infected cell, or protect it from infection, pathogenic effects. The process is simple, and relies on a cell culture system able to support virus growth. Not surprisingly, the *discovery of antivirals parallels the establishment of a robust infected cell based assay. When this was difficult or even not possible (eg., HCV), the use of sub-genomic replicons or surrogate viruses has nevertheless allowed drug discovery and design. There are now a wide variety of assay systems specific for each virus. Robust dengue infected cell assays are available, highly efficient in terms of characterizing the potency of a drug candidate. One significant disadvantage is the cost associated with cell culture reagents and facilities, especially in low income countries. However, this method has an *impressive record of successcompared to other methods. (We are still told there are no antiviral medicines or drugs. Here they mention an impressive record of success– so we need to ask; “What in the world are they talking about”?)
pg. 8,9 Challenges associated with natural products in antiviral research
Whilst natural products as a source of drugs were falling out of favor of pharmaceutical companies, the interest of this source was growing dramatically in countries were these resources are located, ie., mostly low income countries of the developing world. The main incentive was the adoption of the Convention on Biological diversity, enforced in 1993. The challenges associated with this resource are technical and policy issues(3).
On the technical side, the difficulty to deal with natural extracts has been developed above. There are now an increasing number of methods reporting how to prepare an extract suitable to specific needs, including antiviral research. Here also, technology has helped in the preparation of extract libraries.
pg. 11 The introduction of dengue as a druggable disease
Dengue fever is not enough recognized as a major viral disease in terms of public health and economic burden, although the situation is currently changing. The Jain PharmaBiotech report on “Antiviral Therapeutics: Technologies, Companies, and Markets (February 2010)”r mentions dengue within only 2 pages out of >450. However, the more aggressive expansion of the disease in the world, as well as the emergence of a market, are attracting attention of novel actors in the field from both academic and corporate world. *There is no vaccine nor treatment available, and projections are that both will be available approximately at the same time, ie., within ~5 years. *(This is the evil we live and die with; “There is no vaccine nor treatment available….”!)
pg. 11, 12 Current treatment
The treatment is essentially supportive, and there is a very important challenge in estimating the severity of the disease as early as possible. Indeed, unlike most other diseases, a key stage of the disease is the patient’s defervescence during which increased vascular permeability may appear whilst viral load and body temperature (fever) are declining. Close surveillance of this phase, which may need intravascular fluid replacement and maintenance of good haemodynamic stability, is crucial for disease outcome. Disease surveillance and characterization will certainly be key in the implementation of an effective and appropriate antiviral therapy. Much is to be learned about targeting the virus in specific tissues (liver, heart, brain,…) with appropriate antivirals in the future. The increasing knowledge about the host response to a dengue infection is expected to bring most useful care and support to dengue patients, whereas knowledge of DENV components and life-cycle *will eventually lead to efficient antivirals, most probably in combination with those targeting cellular targets (see section “The cellular targets for antiviral research against dengue”) (Antiviral treatments are already known– just that they are not patentable so they are kept in disdain by outdated health destructive endorsed treatments that border on malpractice, if indeed, are malpractice.)
Certainly there will be questions and comments. If you’ve had an experience with dengue fever, please consider sharing your encounter with us. We would like to hear from people who were told; “There is no cure for dengue fever”.
Alert– for accredited scientific studies and research by institutions and individuals, clicking on the following link is a must— papayaleaves.wordpress.com
About PLXC-CTC Dengue Remedies
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Disclaimer: As a Great-grandfather family webmaster, what I share should never be accepted as being medical advice, merely a sharing of easily re–searchable links for the purpose of educational sharing in the public interest.
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